Found in the Karamoja sub-region North East of Uganda, Matheniko Wildlife reserve ranks 5th in the most threatened protected conservation areas in Uganda. Inspite of that, the Lesser Kudu, Roan Antelopes, Bright’s Gazelle and Ostriches (which can only be found only here and in the Kidepo National Park) as well as bird species including the Alpine Chat, Grey-Cuckoo Shrike, and Thick Billed Honey Guide can be seen while touring the reserve.

Matheniko Wildlife Reserve also has some ancient rock paintings said to date back to 3000 years ago.  Birding, nature walks, community and cultural visits are some of the activities to do while at Matheniko wildlife reserve.